Amazing artwork with a great love for details. Of course the clothes of Desmond and Juno are perfectly made, but the background with the effects and the lighting and the slivers which could be like a in-between-world next to the Animus and the real world.
The artwork really implies that Juno has some power over Desmond as his eyes are in the dark and she is with him to guide him – to a good or a bad goal.
Juno's fiery red eyes hint to her inner feelings of anger over humanity. To achieve that she "guides" Desmond to the end. He's the White Knight who will sacrifice himself for humanity. And he is the key to break her from her prison
The artwork really shows the complexity and irony in Demond and Juno's relationship.